Mama Destructo is a professional wrestler in The Gaping M.A.W. league (later a Secret Service agent) and a minor character in Pepper Ann. She is voiced by Kathy Kinney.
Mama Destructo's first appearance on the show is not as a character, but rather a product. In the episode "A Valentine's Day Tune," Lydia Pearson is expecting a heart-shaped cake pan in the mail, but instead receives a pan shaped like Mama Destructo "of Hazelnut Wrestling Federation fame." Lydia hopes that she can modify the cake to look like a Cupid.
The character defining episode for Mama Destructo is "That's My Mama Destructo," where Pepper Ann wins The Gaping M.A.W.'s Tuffstitute Teacher Contest. As a result, Mama Destructo serves as a substitute math teacher at Hazelnut Middle School for two weeks and lives with the Pearson family for that time.
Mama Destructo confides in Pepper Ann that the contest was her idea. Growing up, she idolized her sixth-grade teacher, Miss Elaine Inglebritson and her ability to instill knowledge in her students. She insists that "without her, Mama Destructo would have just been a large, badly-coiffed lump of wasted potential and ignorance." Mama Destructo always hoped to follow in Miss Inglebritson's footsteps and decides to call herself Mama Instructo while she's at Hazelnut Middle School.
Unfortunately, Mama Destructo turns out to be a terrible math teacher. She doesn't understand math and consistently gives the students bad information, to the point where Nicky Little tells her: "Your math is making me violently ill!" One of the rules of her class is that, whenever she "corrects" a student, she uses a wrestling move on them and the student must react as if they were in the ring. As a result, the students begin to learn quite a bit about wrestling, but absolutely nothing about math.
Finally, Pepper Ann confronts Mama Destructo about her poor teaching and a hurt and disillusioned Mama Destructo decides to leave Hazelnut. Pepper Ann convinces her to stay, by having the students put on an elaborate wrestling match. She insists that Mama Destructo is a good teacher...just not a good math teacher.
Mama Destructo then opens Mama Destructo's Spring Backbreaker Wrestling Fantasy Camp, to continue passing on her knowledge of wrestling.
Eventually, Mama Destructo retires from wrestling as the undefeated champion of the world. From there, as we learn in "The Finale," she ultimately becomes a Secret Service agent and is assigned to President Mark Hamill's detail.